Presenting the polygenic risks scores of steroid sensitive nephrotic syndrome (SSNS)

Last week at American Society of Nephrology (ASN) Kidney Week, China Nagano MD, PhD presented our findings on A Multi-Population Polygenic Risk Score for Pediatric Steroid Sensitive Nephrotic Syndrome Is Correlated With Disease Age at Onset. “We are excited to have been part of a global collaboration that both discovered new GWAS loci for pSSNS and created a PRS. We look forward to following up on our discovery in multiple ways,” said China in the ASN Press Release. We couldn’t be prouder - way to go China!

Background: Genome wide association studies (GWAS) have implicated thousands of single nucleotide polymorphisms (SNPs) in common complex diseases and traits. These SNPs can be combined to generate polygenic risk scores (PRS) that can be used for subsequent predictions and clinical association studies. There are no know PRSs of nephrotic syndrome (NS). In this study, we created a multi-population PRS of pediatric steroid sensitive nephrotic syndrome (SSNS) from the largest GWAS of this disease ever conducted and examined its relationship with clinical phenotypes in two independent cohorts.