Get Involved with the Sampson Lab
Learn about how you can work or collaborate with our team
Become a part of our team
We’ve been grateful to have pediatric kidney specialists, computational biologists, biostatisticians, computer scientists, medical students, and undergrads from the US and abroad join our lab over the years. At various stages of training and their careers, these individuals have greatly contributed to our #kidneyomics efforts.
We’re always interested in hearing from people who are interested in working with us. Please be in touch with us via the form below or by emailing matthew.sampson@childrens.harvard.edu.
Collaborate with us
We believe that collaborative research broadens and accelerates scientific discoveries that will ultimately lead to treatments and cures for nephrotic syndrome. If you’re interested in collaborating with us - discussing new ideas, strategies, and projects - we look forward to connecting with you.
Current openings
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The focus of the Sampson Lab at Boston Children’s Hospital/Harvard Medical School is to discover the molecular basis of nephrotic syndrome through human genomics to inform mechanisms, treatments, and cures for this disease (http://sampsonlab.org). We integrate genomics data with other molecular and clinical datasets to discover the biological and clinical impact of the disease-associated genomic variants we discover. We also focus on using large Biobanks to empower genomic discovery for NS. Finally, we are also using new technologies and developing analytic strategies to make definitive genomic diagnoses for patients.
We now seek an intellectually curious and independent thinking post-doctoral fellow to drive forward projects in one or more of these broad research areas.
Specific projects available include:
GWAS and blood and kidney eQTL/pQTL studies of immunosuppressive sensitive NS
Genomic and single cell multiomic analysis of APOL1 mediated kidney disease
Transcriptome-driven genetic diagnosis of nephrotic syndrome
Nephrotic syndrome discovery using population- and hospital-based Biobanks
We are most interested in applicants with excellent skills in biostatistics, as well as a strong understanding of human genetics, bioinformatics, and/or genome biology. They will use both well-established and newer methods for analysis of diverse types of genomic data, including genome and exome sequencing, and bulk and single cell transcriptomics. They will drive their own projects and also support the efforts of other members of the group.
The Sampson Lab is located at Boston Children’s Hospital and is affiliated with Harvard Medical School, the Broad Institute of MIT and Harvard, and Brigham & Women’s Hospital. It is well-funded through multiple Federal grants and other resources. It is a vibrant, highly collaborative, and multidisciplinary environment made up of nephrologists, computational geneticists, biostatisticians, and epidemiologists, and bench researchers.
Responsibilities:
Designing, troubleshooting, and analysis of diverse genomic discovery efforts using our own genomic & phenotypic data & those aggregated from publicly available resources.
Independent thinking and decision making related to study design and analysis
Demonstrate attention to detail and problem-solving skills.
Excellent communication with external collaborators
Preparation of manuscripts, grants, and presentations.
Minimum qualifications:
PhD in biostatistics, biocomputing/bioinformatics, genetics/genomics, or a related field
Experience in any of the following: GWAS, eQTL, single cell analysis, human genetics/genomics, variant calling, rare diseases
Strong communication skills (writing and presenting)
Programming experience in UNIX, R, and/or Python
Familiarity with high-performance and/or cloud computing
Evidence of prior publication(s) and conference/oral presentations
Excellence in collaborating and interacting with others
Preferred qualifications:
Working with bioinformatics analysis pipelines, code version control (e.g., git) tools and/or experience with standard bioinformatic tools (e.g., samtools, PLINK, bedtools)
Familiarity with reproducible data science using Jupyter Notebook or RMarkdown or other
An understanding of biological systems
Interested candidates should send a cover letter & CV to:
matthew.sampson@childrens.harvard.edu
Matt Sampson, MD MSCE ASCI
Warren E. Grupe Chair in Pediatric Nephrology, Boston Children’s Hospital
Associate Professor of Pediatrics and Medicing, Harvard Medical School
Associate Member, Broad Institute
Research Faculty, Brigham and Women’s Hospital
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Full-time postdoctoral positions are available in Dongwon Lee’s laboratory. We study disease-associated genetic variants using computational approaches with a particular focus on transcriptional regulatory mechanisms. We have developed several machine-learning methods for the analysis of regulatory elements and regulatory variants (Lee et al., Nature Genetics 2015; Lee, Bioinformatics 2016; Lee et al., Genome Research 2018; Han et al., PNAS 2022). Projects will include the development of computational methods to model regulatory control of human disease by incorporating improved machine-learning/deep-learning algorithms and single-cell multi-omics data (genomic, transcriptomic, and epigenomic). There will also be ample opportunity to collaborate with clinicians and wet-lab biologists to apply our methods to clinical genetic and genomic data and to validate our computational predictions in model systems.
The applicant should have a Ph.D. degree in computational biology, bioinformatics, bioengineering, biostatistics, computer science, or other related fields.
Strong programming skills in Python, R, C/C++, or equivalent are required.
Experience with Unix/Linux and working with large genetic and genomic data in a high-performance cluster computing environment is highly preferred.
Excellent written and verbal communication skills and a willingness to write grant proposals and manuscripts are necessary.
Interested candidates should send a CV including three references, a cover letter, and representative papers (up to two) to:
dongwon.lee@childrens.harvard.edu
Dongwon Lee, PhD
Assistant Professor of Pediatrics, Division of Nephrology,
Boston Children’s Hospital, and Harvard Medical School
Manton Center Associate, The Manton Center for Orphan Disease Research